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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HLTF
All Species:
26.97
Human Site:
Y531
Identified Species:
45.64
UniProt:
Q14527
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14527
NP_003062.2
1009
113929
Y531
Q
D
I
V
L
T
T
Y
N
I
L
T
H
D
Y
Chimpanzee
Pan troglodytes
XP_001138277
1009
113822
Y531
Q
D
I
V
L
T
T
Y
N
I
L
T
H
D
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534300
1106
124184
Y628
Q
D
I
V
L
T
T
Y
N
I
L
T
H
D
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q6PCN7
1003
113298
Y525
Q
D
I
I
L
T
T
Y
N
I
L
T
H
D
Y
Rat
Rattus norvegicus
NP_001099948
974
110023
Y496
Q
D
I
I
L
T
T
Y
N
I
L
T
H
D
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508504
884
99044
D486
L
K
L
K
P
F
T
D
R
E
W
W
H
R
T
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001090145
999
112576
Y521
Q
D
V
V
V
T
T
Y
S
V
L
S
S
D
Y
Zebra Danio
Brachydanio rerio
XP_693071
942
104740
K511
N
P
N
A
L
Q
S
K
A
V
L
E
L
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P34739
1061
118357
Y579
Y
D
I
V
V
T
T
Y
Q
I
V
A
R
E
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786706
1093
121576
T607
Q
Q
D
V
V
I
T
T
Y
S
T
V
A
A
E
Poplar Tree
Populus trichocarpa
XP_002308876
799
88908
A401
L
D
L
F
S
L
M
A
F
L
R
F
E
P
F
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FF61
881
98598
L483
L
Y
S
L
M
A
F
L
R
F
E
P
F
S
I
Baker's Yeast
Sacchar. cerevisiae
P31244
790
91412
D392
S
K
D
W
K
F
T
D
R
M
H
C
D
H
C
Red Bread Mold
Neurospora crassa
Q7S1P9
1222
137173
D689
A
N
A
A
N
A
P
D
V
I
I
T
S
Y
G
Conservation
Percent
Protein Identity:
100
99.5
N.A.
85.5
N.A.
83.6
81.4
N.A.
71.7
N.A.
64.3
53.1
N.A.
21.1
N.A.
N.A.
34.5
Protein Similarity:
100
99.8
N.A.
88
N.A.
89.7
87.9
N.A.
78.5
N.A.
79.3
69.8
N.A.
41.2
N.A.
N.A.
53.1
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
13.3
N.A.
60
13.3
N.A.
46.6
N.A.
N.A.
20
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
20
N.A.
93.3
26.6
N.A.
73.3
N.A.
N.A.
26.6
Percent
Protein Identity:
33.6
N.A.
N.A.
36
22.7
25.2
Protein Similarity:
50.4
N.A.
N.A.
52.7
40.9
43.9
P-Site Identity:
6.6
N.A.
N.A.
0
6.6
13.3
P-Site Similarity:
26.6
N.A.
N.A.
13.3
13.3
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
15
0
15
0
8
8
0
0
8
8
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
8
% C
% Asp:
0
58
15
0
0
0
0
22
0
0
0
0
8
43
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
8
8
8
8
8
8
% E
% Phe:
0
0
0
8
0
15
8
0
8
8
0
8
8
0
8
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
43
8
8
% H
% Ile:
0
0
43
15
0
8
0
0
0
50
8
0
0
0
8
% I
% Lys:
0
15
0
8
8
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
22
0
15
8
43
8
0
8
0
8
50
0
8
0
0
% L
% Met:
0
0
0
0
8
0
8
0
0
8
0
0
0
0
0
% M
% Asn:
8
8
8
0
8
0
0
0
36
0
0
0
0
0
0
% N
% Pro:
0
8
0
0
8
0
8
0
0
0
0
8
0
8
0
% P
% Gln:
50
8
0
0
0
8
0
0
8
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
22
0
8
0
8
8
0
% R
% Ser:
8
0
8
0
8
0
8
0
8
8
0
8
15
8
8
% S
% Thr:
0
0
0
0
0
50
72
8
0
0
8
43
0
0
8
% T
% Val:
0
0
8
43
22
0
0
0
8
15
8
8
0
0
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
8
8
0
0
0
% W
% Tyr:
8
8
0
0
0
0
0
50
8
0
0
0
0
8
43
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _